Journal: Biomimetics
Article Title: Bone Regeneration Capabilities of Scaffolds Containing Chitosan and Nanometric Hydroxyapatite—Systematic Review Based on In Vivo Examinations
doi: 10.3390/biomimetics9080503
Figure Lengend Snippet: General characteristics of the selected studies.
Article Snippet: Zhao et al. [ ] , Uniform CMCS nanofibers were prepared using polyethylene oxide (PEO), while hydroxyapatite (HA)-coated CMCS nanofibers were prepared by biomimetic mineralization method using 5-times simulated body fluid , Carboxymethyl chitosan (CMCS)–hydroxyapatite (HA) composite nanofibers , Electrospun CS and CMCS had good nanofibrous morphology before mineralization; mineral layer was HA crystals. It was concluded that CMCS nanofibers can effectively regulate the nucleation and growth of apatite from the solution , The evaluation of the scaffold in terms of supporting the differentiation of osteogenic bone-marrow stromal cells (mBMSCs) while monitoring alkaline phosphatase activity was performed in rats with skull defects. , Composite nanofibers promoted new bone formation and maturation.
Techniques: In Vivo, Control, Activity Assay, Emulsion, Membrane, Synthesized, Isolation, Injection, Ex Vivo, Polymer, Pore Size, In Vitro, Suspension, Cell Culture, Light Microscopy